폐쇄성 수면 무호흡의 발병 기전 |
윤대위, 신철 |
1고려대학교 의과대학 인간 유전체 연구소 2고려대학교 의과대학 내과학 교실, 수면장애센터 |
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Mechanisms of obstructive sleep apnea development |
Dae-wui Yoon, Chol Shin |
1Institute of Human Genomic Study, Korea University College of Medicine, Seoul, Korea 2Sleep Disorder Center, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea |
Corresponding Author:
Chol Shin ,Tel: +82-31-412-5603, Fax: +82-31-412-5604, Email: chol-shin@hanmail.net |
Received: June 12, 2009 Accepted: June 25, 2009 Published online: June 30, 2009 |
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ABSTRACT |
Although obstructive sleep apnea (OSA) is a major public health problem, the pathogenesis of OSA is not fully understood. According
to recent studies, development of OSA generally depends on the followings : (1) upper airway anatomy, (2) the ability of upper airway
dilator muscle to respond to stimulation, (3) loop gain, (4) arousal threshold. These factors determine upper airway patency and ventilatory
control stability. Thus, abnormalities in these systems lead to a narrowed, more collapsible pharyngeal airway and ventilator control
instability, which lead in turn to development of OSA. OSA is a heterogeneous disorder which can develop as the result of a variety
of physiologic characteristics, and may differently respond to therapeutic approaches based on the predominant abnormality. Therefore,
the treatment of OSA must be individualized to the cause of the development of OSA. |
Keywords:
Obstructive sleep apnea | Upper airway | Loop gain | Arousal threshold | Ventilatory control stability |
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