| 렘수면행동장애의 치료 |
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문혜진, 남현우 |
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서울대학교 보라매병원 신경과 |
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| Treatment of REM Sleep Behavior Disorder |
| Hye-Jin Moon, Hyunwoo Nam |
| Department of Neurology, Boramae Hospital, Seoul National University, Seoul, Korea |
| Corresponding Author:
Hyunwoo Nam ,Tel: +82-2-870-2471, Fax: +82-2-870-3866, Email: hwnam@brm.co.kr |
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Received: June 4, 2009 Accepted: June 20, 2009 Published online: June 30, 2009 |
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| ABSTRACT |
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REM sleep behavior disorder (RBD) is clinically characterized by the intermittent loss of normal skeletal muscle atonia during rapid
eye movement (REM) sleep with the appearance of elaborate motor activity associated with dream mentation. Clonazepam, a sedating
benzodiazepine, is currently regarded as the treatment of choice for RBD. In patients with contraindications to clonazepam, in those
unresponsive to clonazepam, or in whom tolerance or serious side effects are observed, a therapeutic trial with melatonin up to 12 mg
is recommended. The effect of acetylcholinesterase inhibitors and dopaminergics on RBD symptoms needs future validation. There is
no clear evidence of beneficial effect of bilateral subthalamic nucleus stimulation despite the improvement of the sleep architecture. |
| Keywords:
REM sleep behavior disorder | Clonazepam | Melatonin | Pramipexole | Levodopa |
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